Malaria

What is malaria?

Malaria is a disease caused by a parasite that is transmitted person-to-person by the bite of an infected Anopheles mosquito. These mosquitoes are present in the tropics and subtropics in almost all countries.

Malaria is the most deadly of all tropical parasitic diseases. After the parasites enter the body by a mosquito bite, they disappear from the circulating blood within an hour, and gather in the liver. After several days, infected red blood cells (RBCs) emerge from the liver and infect other RBCs.

What are the different types of malaria parasites?

Four species of malaria parasites can infect humans and cause illness:

Plasmodium falciparum (or P. falciparum)
Plasmodium malariae (or P. malariae)
Plasmodium vivax (or P. vivax)
Plasmodium ovale (or P. ovale)

Generally, only falciparum malaria is potentially life-threatening. Patients with severe falciparum malaria may develop liver and kidney failure, convulsions, and coma. Infections with P. vivax and P. ovale may cause less serious illness, but the parasites can remain dormant in the liver for many months, causing a reappearance of symptoms months, or even years, later.

What are the risks of acquiring malaria?

The risk of acquiring malaria depends on:

traveler's destination
duration of travel
place where the traveler will spend the evenings and nights. (Anopheles mosquitoes bite most often during nighttime hours, from dusk to dawn.)

What are the symptoms of malaria?

Early stages of malaria may be similar to the flu. The following are the most common symptoms of malaria. However, each individual may experience symptoms differently. Symptoms may include:

fever
chills
headache
muscle ache
malaise
nausea
sometimes vomiting, diarrhea, and coughing

The symptoms of malaria may resemble other medical conditions. Always consult your physician for a diagnosis.

How is malaria diagnosed?

In addition to a complete medical history and physical examination, diagnostic procedures for malaria may include blood work to rule out other possible infections.

Can malaria be prevented?

Malaria can often be prevented by the use of antimalarial drugs and use of protection measures against mosquito bites.

medications
When planning to travel to an area where malaria occurs, talk with your physician well in advance of your departure. Drugs to prevent malaria can be prescribed for travelers to malarious areas, but travelers from different countries may receive different recommendations, reflecting differences in treatment protocols as well as availability of medicines in different countries. Travelers visiting only cities or rural areas where there is no risk of malaria may not require preventive drugs, but an exact itinerary is necessary to determine what degree of protection may be needed.

According to the Centers for Disease Control and Prevention (CDC), drugs recommended for prevention of malaria in travelers are: mefloquine, doxycycline, chloroquine, and Malarone^TM. Strict adherence to the recommended doses and schedules of the antimalarial drug selected is necessary for effective protection.
protection from mosquitoes
Be aware that you are still at risk for malaria even with the use of protection.

To avoid mosquito bites, the CDC recommends the following:
- Apply insect repellent to exposed skin. The recommended repellent contains 20 to 35 percent DEET.
- Wear long-sleeved clothing and long pants if you are outdoors at night.
- Use a mosquito net over the bed if your bedroom is not air-conditioned or screened. For additional protection, treat the mosquito net with the insecticide permethrin.
- Spray an insecticide or repellent on clothing, as mosquitoes may bite through thin clothing.
- Spray pyrethrin or a similar insecticide in your bedroom before going to bed.

Note: According to the CDC, vitamin B and ultrasound devices do not prevent mosquito bites.

Treatment for malaria:

Specific treatment for malaria will be determined by your physician based on:

your overall health and medical history
extent of the condition
your tolerance for specific medications, procedures, or therapies
expectations for the course of the condition
your opinion or preference

CDC recommendations for travelers:

Travelers who become ill with a fever during or after travel in a malaria risk area should seek prompt medical attention and should inform their physicians of their recent travel history. Neither the traveler nor the physician should assume that the traveler has the flu or some other disease without completing a laboratory test to determine if the symptoms are caused by malaria.
Malaria symptoms can develop as early as six to eight days after being bitten by an infected mosquito or as late as several months after departure from a malarious area, after antimalarial drugs are discontinued. Malaria can be treated effectively in its early stages, but delaying treatment can have serious consequences.

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