Kidney Biopsy

Kidney Biopsy

(Biopsy-Kidney, Renal Biopsy, Biopsy-Renal, Needle Aspiration of the Kidney, Percutaneous Kidney Biopsy)

Procedure overview

What is a kidney biopsy?

A biopsy is a procedure performed to remove tissue or cells from the body for examination under a microscope. During a kidney biopsy, tissue samples are removed with a special needle to determine if cancer or other abnormal cells are present, or to determine how well the kidney is working.

There are two types of kidney biopsies:

If your doctor wants to sample a specific area of the kidney, the biopsy may be performed in the radiology department, guided by ultrasound, fluoroscopy, or computed tomography (CT scan, a combination of X-rays and computer technology).

Other related procedures that may be used to assess the kidneys include kidney, ureters, and bladder (KUB) X-ray, CT scan of the kidneys, kidney scan, renal ultrasound, renal angiogram, antegrade pyelogram, retrograde pyelogram, intravenous pyelogram, and renal venogram.

How do the kidneys work?

Illustration of the anatomy of the kidney
Click Image to Enlarge

The body takes nutrients from food and converts them to energy. After the body has taken the food that it needs, waste products are left behind in the bowel and in the blood.

The kidneys and urinary system keep chemicals, such as potassium and sodium, and water in balance, and remove a type of waste, called urea, from the blood. Urea is produced when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea is carried in the bloodstream to the kidneys.

Two kidneys, a pair of purplish-brown organs, are located below the ribs toward the middle of the back. Their function is to:

The kidneys remove urea from the blood through tiny filtering units called nephrons. Each nephron consists of a ball formed of small blood capillaries, called a glomerulus, and a small tube called a renal tubule.

Urea, together with water and other waste substances, forms the urine as it passes through the nephrons and down the renal tubules of the kidney. 

Reasons for the procedure

A kidney biopsy may be performed to:

There may be other reasons for your doctor to recommend a kidney biopsy.

Risks of the procedure

As with any surgical procedure, complications can occur. Some possible complications may include, but are not limited to, the following:

If the kidney biopsy is performed with the aid of X-ray technology, the amount of radiation used is considered minimal. Therefore, the risk for radiation exposure is low.

If you are pregnant or suspect you may be pregnant, you should notify your doctor.

Kidney biopsy may be contraindicated in persons with an active kidney infection, certain bleeding conditions, uncontrolled hypertension (high blood pressure), or with only one functioning kidney.

There may be other risks depending on your specific medical condition. Be sure to discuss any concerns with your doctor prior to the procedure.

Before the procedure

During the procedure

A kidney biopsy may be performed on an outpatient basis or as part of your stay in a hospital. The kidney biopsy may be performed in a procedure room, in a hospital bed, or in the radiology department. Procedures may vary depending on your condition and your doctor’s practices.

Generally, a kidney needle biopsy follows this process:

  1. You will be asked to remove clothing and will be given a gown to wear.
  2. An intravenous (IV) line may be started in your arm or hand.
  3. You will be positioned on your stomach so that the doctor can easily reach the kidney. A pillow may be used to hold you in the correct position. If you have a transplanted kidney, you will be positioned on your back.
  4. The skin over the biopsy site will be cleansed with an antiseptic solution.
  5. You will feel a needle stick when the local anesthetic is injected. This may cause a brief stinging sensation.
  6. You will need to lie still during the procedure.
  7. Ultrasound may be used to guide the biopsy needle insertion.
  8. You will be asked breathe in and hold your breath while the doctor inserts the biopsy needle into the kidney. Holding your breath prevents movement of the diaphragm, which may interfere with the placement of the biopsy needle. You should lie quietly without moving.
  9. You may feel discomfort or pressure when the doctor obtains the sample.
  10. There may be more than one puncture performed if the doctor needs more than one tissue sample. If so, the same puncture process will be repeated.
  11. The biopsy needle will be withdrawn and firm pressure will be applied to the biopsy site until the bleeding has stopped.
  12. A sterile bandage or dressing will be applied.
  13. The kidney tissue sample will be sent to the lab for examination.

After the procedure

Your recovery process will vary depending on the type of procedure performed and your doctor’s practices. You may be taken to the recovery room for observation if your procedure was done in a procedure room or in the radiology department. Once your blood pressure, pulse, and breathing are stable and you are alert, you may be taken to a hospital room or discharged to your home.

You will be asked to lie on your back for several hours. A nurse will check your urine for signs of bleeding. You may have blood tests to monitor for internal bleeding. You may be discharged later the same day or the next day.

The biopsy site may be tender or sore for several days after the biopsy. Take a pain reliever for soreness as recommended by your doctor. Aspirin or certain other pain medications may increase the chance of bleeding. Be sure to take only recommended medications.

Notify your doctor to report any of the following:

You may resume your usual diet unless instructed differently. Your doctor may ask you to rest for a day or two and to avoid strenuous physical activity for several days. You should not perform any type of “bouncing” activities such as jogging, aerobics, playing tennis, or horseback riding for a couple of weeks to prevent bleeding of the biopsy site.

Your doctor may give you additional or alternate instructions after the procedure, depending on your particular situation.

Online resources

The content provided here is for informational purposes only, and was not designed to diagnose or treat a health problem or disease, or replace the professional medical advice you receive from your doctor. Please consult your health care provider with any questions or concerns you may have regarding your condition.

This page contains links to other websites with information about this procedure and related health conditions. We hope you find these sites helpful, but please remember we do not control or endorse the information presented on these websites, nor do these sites endorse the information contained here.

American Cancer Society

American Urological Association

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes of Health (NIH)

National Kidney Foundation


Top of Page return to top of page